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Three-drug, low-dose, fixed-combination product is effective for BP control

October 2, 2018
  • Advising on this article:
  • Eric MacLaughlin

KEY POINT

A three-drug, low-dose, fixed-combination dosage form resulted in better blood pressure (BP) control at 6 months compared with usual care in patients with mild to moderate hypertension, according to results of a randomized trial published in JAMA.

SOURCES

Webster R, et al. Fixed low-dose triple combination antihypertensive medication vs usual care for blood pressure control in patients with mild to moderate hypertension in Sri Lanka: A randomized clinical trial. JAMA. 2018;320(6):566–79.

Huffman MD, et al. Low-dose combination blood pressure pharmacotherapy to improve treatment effectiveness, safety, and efficiency. JAMA. 2018;320(6):552–4.

Whelton PK, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71(6):1269–1324.

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