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Factors that may predict sustained efficacy after a short course of OTC PPIs

November 27, 2018
  • Advising on this article:
  • Tara Whetsel

KEY POINT

Heartburn resolution within 7 days following completion of a 2-week course of OTC proton pump inhibitor (PPI) therapy (i.e., esomeprazole) was more common in patients who had less baseline heartburn frequency, in those who had symptom resolution during the last 7 days of treatment, and in patients who had the most heartburn-free days during the 2-week treatment period, according to results of a post-hoc analysis published in BMC Gastroenterology.

SOURCES

Peura DA, et al. Sustained efficacy following resolution of frequent heartburn with an over-the-counter regimen of esomeprazole 20 mg or placebo for 14 days: two randomized trials. BMC Gastroenterol. 2018; [Epub ahead of print]. 

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