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Celecoxib cardiovascular safety similar to nonselective NSAIDs


In a study involving more than 24,000 patients with osteoarthritis (OA) or rheumatoid arthritis (RA) at increased risk for cardiovascular (CV) disease, use of celecoxib was noninferior to ibuprofen or naproxen concerning CV safety, according to results of the PRECISION trial published online in the New England Journal of Medicine.


Nissen SE, et al. Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis. N Engl J Med. 2016;[Epub ahead of print].

FitzGerald, GA. ImPRECISION: limitations to interpretation of a large randomized clinical trial. Circulation. 2016;[Epub ahead of print].