Drug Interactions Corner

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Clinical Relevance of Aspirin– Ibuprofen Interaction Confirmed


Increased all-cause and cardiovascular mortality is the result when aspirin for cardioprotection is used concomitantly with ibuprofen and other NSAIDs that interfere with aspirin’s antiplatelet activity.


MacDonald TM, Wei L. Effect of ibuprofen on cardioprotective effect of aspirin. Lancet. 2003;361:573–4.

FitzGerald GA. Parsing an enigma: the pharmacodynamics of aspirin resistance [editorial]. Lancet. 2003;361:542–4.

Catella-Lawson F et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;345:1809–17.