Drug Interactions Corner

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Drug interactions with newer oral anticoagulants are a concern


Concurrent use of amiodarone, fluconazole, phenytoin, or rifampin with newer oral anticoagulants (NOACs) such as apixaban (Eliquis—Bristol-Myers Squibb), dabigatran (Pradaxa—Boehringer Ingelheim), or rivaroxaban (Xarelto—Bayer, Janssen), increased the risk of major bleeding compared with use of these anticoagulants alone, according to results of a retrospective cohort study published in JAMA.