Drug Interactions Corner

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  • September 1, 2007

    Patients aged 65 and older are particularly susceptible to drug–drug interactions because of pharmacokinetic and pharmacodynamic changes, polypharmacy, and comorbidities. Pharmacists need...

  • July 1, 2007

    Another large study adds to the growing confusion regarding the extent and clinical significance of an interaction between clopidogrel and the HMG-CoA reductase inhibitors (statins).

  • May 1, 2007

    Pharmacokinetic and metabolic studies in patients indicate that smoking cigarettes may have a decreased response exposure to irinotecan therapy, which may result in decreased therapeutic...

  • March 1, 2007

    Drug–drug interactions leading to aspirin and clopidogrel resistance have been reported in the literature. Used together, combinations such as aspirin plus NSAIDs and clopidogrel plus...

  • January 1, 2007

    Drugs that are inhibitors of cytochrome P450 (CYP) enzymes, particularly CYP3A4, are known to increase serum concentrations of several of the HMG-CoA reductase inhibitors (“statins...