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Multiple courses of antenatal corticosteroids: Too much of a good thing?


A single course of antenatal corticosteroids may reduce the risk of respiratory distress syndrome and neonatal death. The benefits of multiple courses given to women who remain undelivered after a single course remains controversial. A study recently published in Lancet found that multiple courses of antenatal corticosteroids given every 14 days to women at high risk for delivering prematurely (earlier than 37 weeks) do not improve preterm birth outcomes and are associated with significant reductions in birth weight, length, and head circumference when compared with a single course of antenatal corticosteroids.

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