Endocrinology

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Therapies for severe sepsis and septic shock shown to be ineffective and harmful

KEY POINT

Recent data show that commonly used hydrocortisone, 10% pentastarch, and intensive insulin therapies are not effective in treating sepsis or septic shock and can be harmful.

SOURCES

Sprung CL et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358:111–24. 

Finfer S. Corticosteroids in septic shock [editorial]. N Engl J Med. 2008;358:188–90. 

Brunkhorst FM et al. Intensive insulin therapypy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358:125–39. 

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