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Harmful effects of torcetrapib examined

KEY POINT

Harmful effects of torcetrapib are attributed to mineralocorticoid excess and nonfunctional, potentially proatherogenic HDL particles.

SOURCES

Barter PJ et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357:2109–22. 

Rader DJ. Illuminating HDL—is it sill a viable therapeutic target? N Engl J Med. 2007;357:2180–3.