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LDL-C: Treatment Beyond Goal Not Yet Evidence-Based


“The lower the better” is not necessarily a valid assumption when it comes to treating patients with hypercholesterolemia and elevated LDL-C levels. Treating patients to LDL-C levels of 80 mg/dL or lower may provide modest therapeutic benefits, but it comes at a hefty economic price.


Jacobson TA. "The lower the better" in hypercholesterolemia therapy: a reliable clinical guideline? Ann Intern Med. 2000;133:549–54.

Forrester JS et al. The aggressive low density lipoprotein lowering controversy. J Am Coll Cardiol. 2000;36:1419–25.

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