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GERD: When to give PPIs without meals, how to manage PPI–clopidogrel alerts


An 8-week course of once-daily proton pump inhibitor (PPI) therapy should be the initial treatment for gastroesophageal reflux disease (GERD), according to a new guideline. Authors of the guideline wrote that dexlansoprazole (Dexilant—Takeda) and omeprazole-sodium bicarbonate (Zegerid—Santarus, Inc) can be given without regard to meals and that no change is needed to PPI therapy in patients taking clopidogrel.


Katz PO et al. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108:308–28.