Gastroenterology

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PPI cotherapy with warfarin may reduce upper GI bleeding events

KEY POINT

Patients who took a proton pump inhibitor (PPI) with warfarin had a 24% risk reduction for hospitalizations for upper gastrointestinal (GI) bleeding, and those who took warfarin and an antiplatelet agent or NSAID plus a PPI had a 45% risk reduction for hospitalizations for upper GI bleeding compared with patients who did not receive concomitant PPI therapy, according to results of a retrospective analysis accepted for publication in Gastroenterology.