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Antiepileptic drugs can affect bone mineral density

KEY POINT

Many antiepileptic drugs can significantly lower bone mineral densities (BMDs) at fracture-relevant sites in high-risk patients. Advise patients taking these medications to monitor their BMDs and consider use of calcium/vitamin D supplements as appropriate.

SOURCES

Petty SJ et al. Effect of antiepileptic medication on bone mineral measures. Neurology. 2005;65:1358–65.

Sato Y et al. Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy. Neurology. 2001;57:445–9.

Pack AM. Bone disease in epilepsy. Curr Neurol Neurosci Rep. 2004;4:329–34.