Neurology

Back to articles

Pregabalin effective for restless legs syndrome

KEY POINT

In adults with moderate-to-severe restless legs syndrome (RLS), pregabalin (Lyrica—Pfizer) 300 mg daily was associated with greater symptom improvement compared with placebo at 12 weeks and with lower rates of augmentation (i.e., worsening of RLS symptoms with drug treatment) compared with pramipexole (Mirapex—Boehringer Ingelheim) 0.5 mg (but not 0.25 mg) per day at up to 52 weeks of treatment.

SOURCES

Allen RP et al. Comparison of pregabalin with pramipexole for restless legs syndrome. N Engl J Med. 2014;370:621–631.