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Pregabalin not effective for acute sciatica


Use of pregabalin (Lyrica—Pfizer) in patients with moderate to severe acute sciatica was no better than placebo at improving leg pain intensity, according to results of the PRECISE study published in the New England Journal of Medicine.


Mathieson S, et al. Trial of pregabalin for acute and chronic sciatica. N Engl J Med. 2017;376(12):1111–20.

Attal N, et al. Is pregabalin ineffective in acute or chronic sciatica. N Engl J Med. 2017;376(12):1169–70.