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Benefits of genotype-guided warfarin dosing still unclear

KEY POINT

Two late-breaking clinical trials presented at the 2013 American Heart Association Scientific Sessions and simultaneously published in New England Journal of Medicine yielded conflicting results regarding clinical utility of genotype-guided dosing of warfarin to improve anticoagulation control.

SOURCES

Pirmohamed M et al. A randomized trial of genotype-guided dosing of warfarin. N Engl J Med. 2013;[Epub ahead of print]. 

Kimmel SE et al. A pharmacogenetic versus a clinical algorithm for warfarin dosing. N Engl J Med. 2013;[Epub ahead of print].

Verhoef T et al. A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon. N Engl J Med. 2013;[Epub ahead of print]. 

Furie B. Do pharmacogenetics have a role in the dosing of vitamin K antagonists [editorial]? N Engl J Med. 2013; [Epub ahead of print].