Pharmacogenomics Corner

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New guidelines: How to interpret genotyping results in patients taking carbamazepine

KEY POINT

Patients who test positive for at least one copy of the human leukocyte antigen-B gene variant allele, HLA-B*15:02, are at increased risk for carbamazepine-induced Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Carbamazepine should be avoided in these patients unless benefits clearly outweigh the risk, regardless of patient age or ancestry.

SOURCES

Leckban SG et al. Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing. Clin Pharmacol Ther. 2013; May [Epub ahead of print].