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Should FDA backpedal on citalopram warning? New study shows higher doses not associated with arrhythmia, death

KEY POINT

Citalopram (Celexa—Forest; various generics) doses greater than 40 mg daily were not associated with increased risk of ventricular arrhythmia or all-cause, cardiac, or noncardiac mortality as compared to lower doses in a large population of individuals receiving treatment for depression within the Veterans Health Administration (VHA).

SOURCES

Zivin K et al. Evaluation of the FDA warning against prescribing citalopram at doses exceeding 40 mg. Am J Psychiatry. 2013;170:642–50.

Temple R et al. Removal from labeling of 60-mg citalopram dose. Pharmacoepidemiol Drug Saf. 2012;21:784–6.

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