Should SSRIs be stopped before surgery to lower bleeding risks?
KEY POINT
In a large population of adults who underwent major surgery, perioperative use of selective serotonin reuptake inhibitors (SSRIs) was associated with increased odds of bleeding, in-hospital mortality, and readmission at 30 days.
SOURCES
Auerbach AD et al. Perioperative use of selective serotonin reuptake inhibitors and risks for adverse outcomes of surgery. JAMA Intern Med. 2013;Epub ahead of print.
Mrkobrada M et al. Selective serotonin reuptake inhibitors and surgery: to hold or not to hold, that is the question [commentary]. JAMA Intern Med. 2013;Epub ahead of print.
