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Switching antidepressants quickly in nonresponders may improve remission rate


In patients with major depressive disorder who did not respond to initial treatment, switching to a new antidepressant at 4 weeks led to a similar time to confirmed response and remission as switching at 8 weeks. Patients who were switched early had a higher rate of confirmed remission at study end.


Romera I et al. Early switch strategy in patients with major depressive disorder: a double-blind, randomized study. J Clin Psychopharmacol. 2012;32:479–86.