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Batch-to-batch variability a concern with dry powder inhalers

KEY POINT

Results of a pharmacokinetic (PK) study assessing batch-to-batch variability among three different batches of fluticasone/salmeterol (FP/SAL) dry powder inhalers (DPIs) (Advair Diskus 100/50—GlaxoSmithKline) showed that between-batch variability was significant and may be related to the age of the inhaler, with the oldest batch yielding the lowest systemic exposure.

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