Medication Monitor

Generic Name (Trade Name—Company)
May 8, 2013

Prostaglandin E, papaverine, phentolamine

(TriMix-gel—TriMix Laboratories )
Topical option now available for erectile dysfunction

TriMix Laboratories announced the release of combination prostaglandin E, papaverine, and phentolamine for the treatment of erectile dysfunction (ED) in patients who cannot tolerate self-injection with a needle or for whom phosphodiesterase type 5 inhibitors such as sildenafil, vardenafil, or tadalafil do not work.

Each dose contains TriMix in powder form, which becomes a gel when applied. In liquid form, TriMix is a smooth muscle relaxant that increases intracellular cyclic adenosine monophosphate levels. This leads to expansion of the lacunar spaces and entrapment of blood by compressing the venules against the tunica albuginia.

TriMix-gel, available in a 2,000-µg dose, should be compounded by a licensed pharmacy and shipped directly to the patient.