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Combination beta agonists and anticholinergics better than beta agonists alone for acute asthma


A Cochrane systematic review concluded that combination therapy with a short-acting beta agonist (SABA) and a short-acting anticholinergic (SAAC) was more effective at reducing the rate of hospitalizations and improving lung function compared with SABA treatment alone for adults presenting to the emergency department (ED) for acute management of severe asthma exacerbations. However, the combination regimen was associated with more adverse events.


Kirkland SW, et al. Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma. Cochrane Database Syst Rev. 2017; 1:CD001284.